A novel structure-based approach for identification of vertebrate susceptibility to SARS-CoV-2: Implications for future surveillance programmesSARS-CoV-2에 대한 척추동물 감수성 식별을 위한 새로운 구조 기반 접근 방식: 미래 감시 프로그램에 대한 의미Article Published on 2022-09-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach binding affinity conservation contribute coronavirus Critical Cross-species transmission debatable dissociation Dissociation constant domain facilitate facilitated genetic determinant genetic determinants highlight Host host cell host cell receptor host cells host range hosts in vivo Intensive interacting residue Interaction isoform Ligand mechanism molecular interaction Outbreaks Pathogens Prevent profile Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Scientific community severe acute respiratory syndrome Coronavirus spike Spike protein Surveillance susceptibility susceptible the SARS-CoV-2 understanding Vertebrate Vertebrate species. viral evolution virus entry zoonotic pathogens [DOI] 10.1016/j.envres.2022.113303 PMC 바로가기 [Article Type] Article
Host genomics of SARS-CoV-2 infectionSARS-CoV-2 감염의 숙주 유전체학Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute infection approach approaches association Asymptomatic causal variant complications COVID-19 COVID-19 pneumonia demographic disease disease severity downstream Exome explain exploration Factor fraction functional genetic determinant genetic determinants Genetic variant Genome sequencing Genome-wide association studies genomic study highlighting host-virus interactions Human human genetic variation immune function individuals International involved life-threatening locus management Mild outcome pandemic Pathogenesis pathway Pathways Pneumonia Region required SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection SARS-CoV-2 pathogenesis severe cases shown therapeutic targets type I interferon type I interferon response Variability with COVID-19 [DOI] 10.1038/s41431-022-01136-4 PMC 바로가기 [Article Type] Review
Clinical and Genetic Characteristics of Coronaviruses with Particular Emphasis on SARS-CoV-2 VirusSARS-CoV-2 바이러스에 특히 중점을 둔 코로나바이러스의 임상 및 유전적 특성Review Published on 2022-06-192022-09-11 Journal: Polish journal of microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] caused clinical clinical courses coronavirus disease Coronavirus disease 2019 Course courses COVID-19 Culture diagnostics effort epidemiological situation Genetic genetic determinant genetic determinants Health Health crisis Infection knowledge mechanism pandemic Particular prevention of COVID-19 Research SARS-CoV-2 severity Society susceptibility the disease Treatment Vaccine vaccine. virus transmission [DOI] 10.33073/pjm-2022-022 PMC 바로가기 [Article Type] Review
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions전사체 연구에 따르면 COVID-19가 주요 건강 상태에 미치는 병태생리학적 영향Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ADAM8 Analysis association canakinumab Captopril Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 progression diabetes Diabetes Mellitus disease downregulation drug candidate dysregulated Factors gene expression analyses Genes genetic determinant genetic determinants health condition hypertension Inflammatory responses influence influences IRF7 lung cancer mechanism METTL7A Microarray microarray. MicroRNAs molecular basis MX2 Myocardial infarction notable outcome Pathogenesis pathophysiological Pathways patients Potential biomarker potential biomarkers PPARGC1A predominant prevalent prognostic provide Regulatory rilonacept RNA-Seq SARS-CoV-2 severity shared pathway shared pathways signaling pathway therapeutic transcription factor transcription factors upregulated gene upregulated genes upregulation [DOI] 10.1093/bib/bbab197 PMC 바로가기 [Article Type] Article
Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE ResidentsUAE 거주자 사이의 비타민 D 대사 경로의 유전적 변이와 COVID-19의 심각성 간의 연관성Article Published on 2021-10-202022-09-10 Journal: Nutrients [Category] MERS, 바이오마커, 변종, 유전자 메커니즘, [키워드] 25-hydroxyvitamin D affected association Cell COVID-19 COVID-19 severity Critical CYP2R1 deficiency Effect Factor genetic determinant genetic determinants genetic variants Genetic variation Genetic variations genotype data genotypes hospital Human immune system implicated Infection investigated involved mechanism mechanism of action metabolism NADSYN1 outcomes Patient patients with SARS-CoV-2 polymorphism Population potential risk Research resident SARS-CoV-2 SARS-COV-2 infection serum serum 25-hydroxyvitamin D severe COVID-19 severity of COVID-19 single-nucleotide Single-nucleotide polymorphisms Spread two groups UAE United Arab Emirate United Arab Emirates vaccination variant VDR Viral viral infection Vitamin D vitamin D deficiency Vitamin D Metabolism Vitamin D status [DOI] 10.3390/nu13113680 PMC 바로가기 [Article Type] Article
Personalized therapy: can it tame the COVID-19 monster?맞춤 요법 : Covid-19 Monster를 길들일 수 있습니까?Review Published on 2021-10-152022-09-10 Journal: Personalized Medicine [Category] SARS, 신약개발, 치료제, [키워드] adverse effect adverse effects age antivirals Biomarker Biomarkers clinical trials COVID-19 COVID-2019 drug Drug repurposing drug toxicity drugs genetic determinants Infection knowledge morbidity and mortality mortality rates pathogen Personalized medicine precision therapy SARS-CoV-2 SARS-COV-2 infection Sex subjects therapeutic efficacy therapy thought Toxicity virus zoonotic [DOI] 10.2217/pme-2021-0077 PMC 바로가기 [Article Type] Review
The TNFRSF13C H159Y Variant Is Associated with Severe COVID-19: A Retrospective Study of 500 Patients from Southern ItalyTNFRSF13C H159Y 변이체는 심각한 COVID-19와 관련이 있습니다: 남부 이탈리아에서 온 500명의 환자에 대한 후향적 연구Communication Published on 2021-06-082022-09-10 Journal: Genes [Category] MERS, 변종, 유전자 메커니즘, [키워드] TNFRSF13C Activation allele analyzed asymptomatic subject B-cell build coding sequence coding sequences contribute COVID-19 CVID disease severity examined genetic determinant genetic determinants genetic risk factor genotyped hospitalized patients Host Humoral immunity identify immunodeficiency involved Italy management mechanism NF-kB non-severe patient pathogenic Point mutation positive predicted rationale risk SARS-CoV-2 Severe case severe COVID-19 Severe patient severe patients severity significant enrichment significantly more SNP genotyping subject the disease therapy TNFRSF13C variant whole-exome sequencing [DOI] 10.3390/genes12060881 PMC 바로가기 [Article Type] Communication
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization studyCOVID-19 Host Genetics Initiative의 비타민 D 및 COVID-19 감수성 및 심각성: 멘델식 무작위 배정 연구Research Article Published on 2021-06-012022-08-13 Journal: PLoS Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 2-sample MR 25-hydroxy vitamin D 25OHD 25OHD level 25OHD levels 95% CI analyses Analysis association associations circulating confounder confounders confounding variables Control control group control groups controlled trials controls COVID-19 COVID-19 case COVID-19 cases COVID-19 Host Genetics Initiative COVID-19 susceptibility deficiency described determined by ecological Ecological studies European Evidence General population Genetic genetic determinant genetic determinants genetic evidence genetic instrument genetic instruments Genetic variant genetic variants Genome-wide association study Guillaume GWAS GWASs had no horizontal pleiotropy Hospitalization IMPROVE in some in vitro Increased individual individuals with COVID-19 initiative instrument bia instrumental variables inverse-weighted MR Laboratory testing large-scale vitamin D randomized trials limit logarithmic scale mendelian randomization Mendelian randomization studies Mendelian randomization study meta-analytic methods observational studies observé Odds ratio Other outcome outcomes participant Population predicted PROTECT provide provided Randomized controlled trial Randomized controlled trials randomized trials rationale reduce reflected removal researcher risk SARS-CoV-2 positivity Sensitivity analyses sensitivity analysis severe disease severity Standard deviation Support supported susceptibility therapeutic therapy trials UK biobank variant variants Vitamin D vitamin D deficiency vitamin D level vitamin D levels Vitamin D Mendelian randomization vitamin D Mendelian randomization studies Vitamin D supplementation vitamin D supplementation randomized trials was determined were used with COVID-19 worsened [DOI] 10.1371/journal.pmed.1003605 PMC 바로가기 [Article Type] Research Article
Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry비교 분석을 통해 SARS-CoV-2 진입에 필요한 ACE2의 종별 유전적 결정인자가 밝혀졌습니다.Research Article Published on 2021-03-242022-08-13 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 protein ACE2 proteins ACE2 sequence animal model binding can not cell entry cellular receptor Comparative analysis coronavirus Critical facilitate functional Genetic genetic determinant genetic determinants genetic engineering host cell host range Human human ACE2 Interaction koala limit mammalian mouse New World New World monkey receptor receptor function replaced REPLACED BY required residue restored restrict reveal SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein sequences shown Spike protein Support the spike protein Thr tissue tropism Viral viral entry viral spike protein [DOI] 10.1371/journal.ppat.1009392 PMC 바로가기 [Article Type] Research Article